II Simpósio Brasileiro de Neuropsicofarmacologia

Below are links containing some pictures taken during the II SBNP, many thanks to the “voluntary photographers”:

1- Fotos by Prof. Francisco Guimarães–https://www.dropbox.com/sh/ehst2knsy9sufwq/AAD6vlXhM4ZpE0nzARvWTBrda?dl=0

Caros  participantes,

Os certificados do II Simpósio Brasileiro de Neuropsicofarmacologia estão prontos e se encontram no link abaixo, que também foi enviado a seus E-mails:

CERTIFICADOS AQUI!

Até o próximo evento!

Chairs: Alline Campos (USP), Geison Izídio (UFSC), Greg Wegener (Aarhus University, Denmark)

All posteres should be hang there in the morning. Presentation times are as follows:

Morning (10:00-11:00): posters 1-19

1 -ROLE OF NITRIC OXIDE IN THE ACQUISITION OF OLFACTORY AVERSIVE CONDITIONING INDUCED BY N-METHYL-D-ASPARTATE INFUSION INTO THE PERIAQUEDUCTAL GRAY MATTER Lucía Acuña1, Antonio P. Carobrez1 1Laboratory of Behavioral Neurobiology. Department of Pharmacology / CCB, UFSC, Florianópolis, SC, Brazil
2- ANTIDEPRESSANT-LIKE EFFECT OF GUANOSINE INVOLVES ACTIVATION OF AMPA RECEPTORS AND BDNF/TRKB PATHWAY Priscila B. Rosa1, Luis E. B. Bettio2, Vivian B. Neis1, Morgana Moretti1, Isabella A. Heinrich1, Andiara E. Freitas1, Mauren K. Tavares1, Rodrigo B. Leal1, Ana Lúcia S. Rodrigues1 1Department of Biochemistry, Center of Biological Sciences, Universidade Federal de Santa Catarina, Florianópolis, 88040-900, SC, Brazil. 2 Current address: Division of Medical Sciences, University of Victoria, Victoria, BC, Canada

3- ULIGINOSIN B INHIBITS ATP AND ADP HYDROLYSIS ON STRIATAL SYNAPTOSOMES OF RATS Camila Pires Machado da Silva1, Roberta Andrejew2, Caroline Guerra Marangon1, Gilsane Lino Von Poser1, Ana Maria Oliveira Batasttini2, Stela Maris Kuze Rates1 1Graduate Program in Pharmaceutical Sciences, Federal University of Rio Grande of Sul-UFRGS, Porto Alegre, RS, Brazil. 2 Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande of Sul-UFRGS, Porto Alegre, RS, Brazil.

4- PARTICIPATION OF THE P2X7-NLRP3 INFLAMMASOME PATHWAY IN STRESS SUSCEPTIBILITY AND ANTIDEPRESSANT RESPONSE IN THE LEARNED HELPLESSNESS MODEL : Roncalho AL1; Côrrea-Velloso JC2,3; Lacchini R4; Chiavegatto S5,6; Wegener G7; Joca SRL8 1Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil. 2 Department of Biochemistry, Chemistry Institute, University of Sao Paulo, Sao Paulo, Brazil, São Paulo, Brazil. 3 Department of Pharmacology, Physiology and Neuroscience, New Jersey Medical School, Rutgers, The State University of New Jersey, USA. 4Department of Psychiatric Nursing, Ribeirão Preto College of Nursing, University of Sao Paulo, Ribeirão Preto, Brazil. 5Department of Pharmacology, Biomedical Sciences Institute, University of São Paulo, São Paulo, Brazil 6Department and Institute of Psychiatry, Clinics Hospital, School of Medicine, University of São Paulo, Brazil 7Institute for Basic Psychiatric Research, Department of Biological Psychiatry, Aarhus University, Denmark. 8Department of Physics and Chemistry, School of Pharmaceutical Sciences of Ribeirão Preto, Brazil

5- DO GENETIC VARIATIONS OF THE NLRP3 GENE INTERFERE IN INTERLEUKIN-1Β LEVELS AND MAJOR DEPRESSIVE DISORDER DIAGNOSIS? Bruna C. Pierone1, Fernanda N. Kaufmann1, Clarissa R. Bastos2, Karen Jansen2, Luciano D. M. Souza2, Diogo R. Lara3, Ricardo A. Silva2, Gabriele Ghisleni2, Manuella P. Kaster1 1Department of Biochemistry, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil 2Department of Life and Health Sciences, Catholic University of Pelotas, Pelotas, Rio Grande do Sul, Brazil 3Department of Cellular and Molecular Biology, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil

6-  FLUOXETINE ENHANCES THE ANXIETY-LIKE BEHAVIOR INDUCED BY THE ELEVATED T-MAZE IN MICE Darlei Francisco Stein¹, Ana Luiza de Azevedo Gomes¹ e Stela Maris Kuze Rates¹ Programa de Pós-Graduação em Ciências Farmacêuticas, UFRGS, Brazil

7- THE USE OF RELIABILITY MEASUREMENTS IN THE FORCED SWIM TEST (FST) IN RATS: PROBING THE EFFECTS OF EXPERIENCE ON RATER´S PERFORMANCE. Giancarlo Marchesini1, João A. Marcolan1, Karolina Domingues2, Patrick Suman2, Cilene Lino de Oliveira2, José Marino Neto1 1Institute of Biomedical Engineering, Federal University of Santa Catarina, Florianópolis, SC, Brazil. 2Department Physiological Sciences, Federal University of Santa Catarina, Florianópolis, SC, Brazil.

8- PROLONGED TREATMENT WITH A PHOSPHODIESTERASE 4 INHIBITOR DID NOT INDUCE ANXIETY-LIKE BEHAVIOR OR NEGATIVE AFFECTIVE STATE IN RATS Maryana Albino Clavero1, Camila Pasquini de Souza1, Jos Prickaerts2, Rubia M. W. de Oliveira3, Roberto Andreatini1 1 Department of Pharmacology, Biological Sciences Sector, Federal University of Paraná, Centro Politécnico, C.P. 19031, 81540-990, Curitiba, Paraná, Brazil. 2. Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands. 3. Department of Pharmacology and Therapeutics, State University of Maringá, Av. Colombo, 5790, 87020-900, Maringá, Paraná, Brazil.

9- CB1 RECEPTOR ANTAGONISM PREVENTS HYPERLOCOMOTION INDUCED BY THE DOPAMINE TRANSPORTER INHIBITOR GBR12909 Juliana dos Reis Bastos 1, Nicole Font 1, Antônio Lúcio Teixeira Júnior 4,5, Fabiana Simão Machado 2, Aline Silva de Miranda 3,4, Fabrício de Araújo Moreira 1 1Department of Pharmacology, 2 Department of Biochemistry and Immunology, 3 Department of Morphology, 4 Interdisciplinary Laboratory of Medical Investigation, School of Medicine, Federal University of Minas Gerais – UFMG, BH, MG, Brazil; 5 Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA

10- EVALUATUION OF MICE LIMBIC BRAIN AREAS IN THE MODULATION OF RAT EXPOSURE TEST-EVOKED RESPONSE FERNANDES GJD2, BALBO LC1, BERTAGNA NB2, QUEIROZ RM2, GARCIA BS1, CRUZ FC3, MIGUEL TT1,2 ¹Pharmacology Department, Federal University of Uberlandia (UFU).²Cellular and Structural Applied Biology Graduate Program, UFU.³Psychopharmacology Department, Federal University of Sao Paulo (UNIFESP)

11- BEHAVIORAL AND NEUROCHEMICAL CHANGES IN MICE ADULTHOOD INDUCED BY EARLY LIFE STRESS Platt, N.1; Oliveira, E1.; Camargo, A.1; Kaufmann, F.N.1; Pieroni, B.1; Rosa, P.B.1; Rosado, A.F.1; Olescowicz, G.2; Rodrigues, A.L.S.1; Prediger, R. D. S.2; Brocardo, P.S.3; Kaster, M.P1. 1Department of Biochemistry, Federal University of Santa Catarina – Campus Reitor João David Ferreira Lima – Trindade/Florianópolis – SC, 88040-900 2Department of Pharmacology, Federal University of Santa Catarina – Campus Reitor João David Ferreira Lima – Trindade/Florianópolis – SC, 88040-900 3Department of Neuroscience, Federal University of Santa Catarina – Campus Reitor João David Ferreira Lima – Trindade/Florianópolis – SC, 88040-900

12- IMPACT OF STRESS DURING PREGNANCY ON CHILD DEVELOPMENT: ROLE OF HYPOTHALAMIC-PITUITARY-ADRENAL AXIS ACTIVATION Angelina da Silva Pires, Cristiane Rezende Mochny CESUSC College, Florianópolis, SC, Brazil.

13- COMPARISON OF ADVERSE EVENTS OF VALPROATE SODIUM 300 MG TABLET COATED UNDER FASTED CONDITIONS AND FED AFTER ORAL ADMINISTRATION Patrícia Moura da Rosa Zimmermann1, Emanuelle Menegazzo Webler1, Júlia Pacheco2, Carmen Maria Donaduzzi1, Letícia Mello Rechia1, Antonio Waldo Zuardi2, Liberato Brum Junior1 1 Prati Donaduzzi & Cia LTDA 2 Department of Neuroscience and Behavior, FMRP, University of São Paulo, Ribeirão Preto, SP, Brazil.

14- FOOD DEPRIVATION AND SEARCH FOR PALATABLE FOOD IN FRUIT FLIES: INTERACTIONS BETWEEN SEX AND DURATION OF FASTING Fabiola Boz Eckert1, Daniela Cristina De Toni2, Cilene Lino De Oliveira3, José Marino Neto4. 1Postgraduate Program in Pharmacology, Federal University of Santa Catarina -UFSC, Brazil,2Drosofilids Laboratory, UFSC, Brazil,3Laboratory of Behavioural Neurobiology, UFSC, Brazil, 4Institute of Biomedical Engineering, UFSC, Brazil

15- CHRONIC GLIBENCLAMIDE TREATMENT PREVENTED STRESS-INDUCED CHANGES IN BEHAVIOR AND DOPAMINE LEVELS IN THE PRE-FRONTAL CORTEX OF MICE Axel Fogaça Rosado¹, Fernanda Neutzling Kaufmann¹, Priscila Batista Rosa¹, Vivian Binder Neis¹, Gudrian Ricardo Lopes de Almeida¹, Ingrid Selhorst¹, Alcir Luiz Dafre¹, Ana Lúcia Severo Rodrigues¹, Manuella Pinto Kaster¹ Department of Biochemistry, Federal University of Santa Catarina

16- THE ACUTE EFFECTS OF LOW DOSES OF ∆9-TETRAHIDROCANABINOL IN ANXIETY ARE SEX AND AGE-DEPENDENT Beatriz Zanutto Salviato1, Thiago Rodrigues da Silva1, Ana Maria Raymundi1, Cristina Aparecida Jark Stern1 1Department of Pharmacology, Biological Sciences Center. Federal University of Parana, Curitiba, PR, Brazil.

17- FASTING INCREASE THE PREFERENCE FOR PALATABLE FOOD IN DROSOPHILA MELANOGASTER Fabiani Fernanda Triches1,3; Fabiola Boz Eckert1,3; Mauro Federico Ramírez2; Ana Belen Ramos Hryb3; Daniela Cristina de Toni1; Cilene Lino de Oliveira3 1Drosofilids Laboratory, CCB, Federal University of Santa Catarina, Brazil 2Laboratory of Comparative Neurophysiology, Department of Physiological Sciences, CCB, Federal University of Santa Catarina, Brazil 3Laboratory of Behavioral Neurobiology, CCB, Federal University of Santa Catarina, Brazil

18- ROLE OF µ-OPIOID AND CB1 RECEPTORS OF THE DORSAL PERIAQUEDUCTAL GRAY MATTER IN THE MODULATION OF AVERSIVE AND ANTINOCICEPTIVE RESPONSES INDUCED BY FEAR Godoi, Manuella Machado 1; Cunha, Joice Maria 1,2; Zanoveli, Janaina Menezes, 1,2 1 Department of Pharmacology, Biological Science Sector, Federal University of Paraná, Curitiba, Paraná, Brazil 2 Institute of Neurosciences and Behavior (INeC), University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil

19- MYNOCICLINE PRE-TREATMENT DID NOT PREVENT THE BEHAVIORAL CHANGES INDUCED BY HIGH-REFINED CARBOHYDRATE DIET CONSUMPTION IN MICE Nícia Pedreira Soares1; Anna Paula Marçal1; Rafaela Pinto Coelho Santos1 Laila Asth1, Daniele Cristina de Aguiar1 1Laboratory of Neuropsychopharmacology (LNP), Department of Pharmacology, Institute of Biological Sciences (ICB), Federal University of Minas Gerais (UFMG), Minas Gerais, Brazil

Afternoon  (15:30-16:30): posters 20-36

20- A SINGLE INJECTION OF THE ORGANOPHOSPHORUS TRIAZOPHOS INDUCES A DEPRESSIVE, BUT NOT AN ANXIOUS-LIKE BEHAVIOR IN RATS Anna Paula Perin Vidigal, Julia Gomes dos Santos, João Vitor Ferreira Rodrigues, Vitor Sampaio Minassa, Thatiany Jardim Batista, Karla Nívea Sampaio, Vanessa Beijamini Harres Pharmaceutical Sciences Graduate Program, Health Sciences Center, Federal University of Espirito Santo, Vitoria, Brazil

21- VERTICAL CLIMBING: MEASURING THE MOTIVATION OF RATS IN AN EFFORT TASK Tamires Martins1; Renato Fiacador de Lima1; Cilene Lino de Oliveira1. 1 Department of Physiological Sciences, Center of Biological Science, Federal University of Santa Catarina, Florianópolis, Brazil.

22- THE USE OF RELIABILITY METRICS FOR OBSERVATIONAL STUDIES IN RATS SUBMITTED TO THE FORCED SWIM TEST (FST): A SYSTEMATIC REVIEW. Giancarlo Marchesini1, Cilene Lino de Oliveira2, José Marino Neto1 1Institute of Biomedical Engineering, Federal University of Santa Catarina, Florianópolis, SC, Brazil, 2Department Physiological Sciences, Federal University of Santa Catarina, Florianópolis, SC, Brazil

23- CANNABIDIOL AS A POTENTIAL THERAPEUTIC AGENT IN THE TREATMENT OF DEPRESSION AND ANXIETY ASSOCIATED WITH DIABETES Yane Chaves1, Karina Genaro2,3, Cristina Stern1, José Alexandre Crippa4,5, Joice Maria Cunha1,2, Janaína Menezes Zanoveli1,2 1Department of Pharmacology, Biological Science Sector, Federal University of Paraná, Curitiba, Paraná, Brazil, 2Institute of Neurosciences and Behavior (INeC), University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil, 3University of California, Irvine, Department of Pharmacology, Irvine, California, United States of America, 4Department of Neuroscience and Behavioral Sciences, Ribeirão Preto Medical School, University of São Paulo, Brazil, 5National Institute of Science and Technology for Translational Medicine (INCT-TM-CNPq), Ribeirão Preto, São Paulo, Brazil

24- ACUTE TREATMENT WITH CANNABIDIOL DID NOT PREVENT THE COMPULSIVE-LIKE BEHAVIOR IN MICE AFTER CONSUMPTION OF HIGH-REFINED CARBOHYDRATE DIET Anna Paula Marçal1; Nícia Pedreira Soares1; Dayane Araújo1; Daniele Cristina de Aguiar1 Laboratory of Neuropsychopharmacology (LNP), Department of Pharmacology, Institute of Biological Sciences (ICB), Federal University of Minas Gerais (UFMG), Minas Gerais, Brazil

25- SEX DIFFERENCES IN THE BEHAVIORAL RESPONSE OF SEROTONERGIC INHIBITION OF THE MEDIAL PRE-FRONTAL CORTEX IN RATS SUBMITTED TO THE FORCED SWIMMING TEST Karolina Domingues1, Fernando Falkenburger Melleu2, Patrick Remus Suman1, Tamires Martins1, Cilene Lino de Oliveira1 1Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil; 2Universidade de São Paulo, São Paulo, SP, Brazil

26- A PROTOCOL FOR THE SYSTEMATIC REVIEW AND META-ANALYSIS OF THE EVIDENCE LINKING HIPPOCAMPAL NEUROGENESIS TO THE EFFECTS OF ANTIDEPRESSANTS ON MOOD AND BEHAVIOR Juliana Aparecida Bolzan1, Cilene Lino de Oliveira2 ¹ Master student in Pharmacology. Laboratory of Behavioral Neurobiology, Labnec-CFS-CCB-UFSC- Florianopolis-SC-Brazil. E-mail: ² Advisor of the Graduate Program in Pharmacology. Laboratory of Behavioral Neurobiology, Labnec-CFS-CCB-UFSC- Florianopolis-SC-Brazil.
27- BEHAVIOURAL EVALUATION AND SEXUAL DIFFERENCES AFTER MATERNAL SEPARATION IN WISTAR RATS Patrick Remus Suman¹,², Tamires Martins², Karolina Domingues¹,², Cilene Lino de Oliveira¹,³ 1.Department of Pharmacology, Center of Biological Sciences, Federal University of Santa Catarina – UFSC, Florianópolis, SC, Brazil 2. Department of Physiological Sciences, Center of Biological Sciences, Federal University of Santa Catarina – UFSC, Florianópolis, SC, Brazil
28- THE MONOAMINE STABILIZER, OSU-6162, REDUCES COCAINE-INDUCED HYPERLOCOMOTION AND ACQUISITION OF CONDITIONED PLACE PREFERENCE IN MICE Laila Asth1, Nícia Pereira Soares1, Anna Paula Marçal1, Daniele Cristina Aguiar1, Fabrício de Araújo Moreira1 1Laboratory of Neuropsychopharmacology, Department of Pharmacology, ICB, Federal University of Minas Gerais, Brazil
29- THE USE OF ANTIDEPRESSANTS IN THE PRIMARY CARE: PROFILE OF USERS IN A MUNICIPALITY IN THE WEST OF SANTA CATARINA Patrícia Prevedello 1, Cilene Lino de Oliveira 2 1 Municipality of Maravilha, Primary care pharmacist, Maravilha, SC, Brazil, 2 Department of pharmacology, CCB, UFSC, Florianópolis, SC, Brazil

30- THE ANTIDEPRESSANT EFFECT OF KETAMINE IN SWISS MICE IN THE FORCED SWIM TEST: SYSTEMATIC REVIEW AND META-ANALYSIS OF LITERATURE EVIDENCE Silva, Marcus Antônio Bezerra1; Zerbinatti, Nathália1; Suman, Patrick Remus1; Lino de Oliveira, Cilene1 Department of Physiological Sciences, Federal University of Santa Catarina, Florianopolis, SC, Brazil.

31-AEROBIC EXERCISE ATTENUATES HYPERALGESIA SIGNS INDUCED BY FIBROMYALGIA MODEL Eduarda Gomes Ferrarini1,2, Elaine Cristina Dalazen Gonçalves1,2, Jaíne Ferreira Menegasso1, Rafael Cypriano Dutra1,2 1 Laboratório de Autoimunidade e Imunofarmacologia, Departamento de Ciências da Saúde, Universidade Federal de Santa Catarina, Campus Araranguá, Araranguá, SC, Brasil. 2 Programa de Pós-Graduação em Neurociências, Centro de Ciências Biológicas, Campus Florianópolis, Universidade Federal de Santa Catarina, Florianópolis, SC, Brasil.
32- OXYTOCIN RECEPTOR MODULATES ANXIOGENIC LIKE BEHAVIOR IN PSYCHOLOGICAL STRESS Ivaldo Jesus Almeida Belem-Filho1, Alana Tercino Frias1, Hélio Zangrossi-Junior1, Jose Antunes-Rodrigues2, Fernando Morgan de Aguiar Corrêa1 1Department of Pharmacology, Faculty of Medicine of Ribeirão Preto, Ribeirão Preto, São Paulo, Brazil, 2Department of Physiology, Faculty of Medicine of Ribeirão Preto, Ribeirão Preto, São Paulo, Brazil.
33- POTENTIAL ANTIMANIAC EFFECT OF QUERCETIN ON HYPERLOCOMOTION INDUCED BY OUABAIN IN ANIMAL MODELS OF MANIA Vivian C. Monteiro Pereira1, Roberto Andreatini1, Ana Paula Segantine1 1Department of Pharmacology, Federal University of Paraná/UFPR, Curitiba, PR, Brazil.
34- THE ANTIDEPRESSANT EFFECT OF RAPANEA FERRUGINEA AND ITS MAJORITARY COMPOUND MYRSINOIC ACID B IN DIABETIC RATS IS ASSOCIATED WITH A REDUCTION OF THE OXIDATIVE STRESS IN THE PREFRONTAL AND HIPPOCAMPAL CORTICES Priscila Laiz Zimath¹; Ana Paula Dalmagro²; Luisa Mota Silva²; Angela Malheiros²; Márcia Maria de Souza². ¹ Programa de Pós Graduação em Farmacologia, Universidade Federal de Santa Catarina, SC, Brasil. ² Programa de Pós Graduação em Ciências Farmacêuticas, Universidade do Vale do Itajaí, SC, Brasil.
35- MODULATION OF THE NOP RECEPTOR SIGNALING AFFECTS STRESS COPING RESPONSES IN MICE: IMPLICATIONS FOR RESILIENCE TO STRESS Holanda VAD1, Pacifico S2, Azevedo Neto J3, Finetti L4, Calo’ G3, Ruzza C3, Gavioli EC1 1Behavioral Pharmacology Laboratory, Department of Biophysics and Pharmacology, Federal University of Rio Grande do Norte, Natal, Brazil; 2Department of Chemistry and Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy; 3Department of Medical Sciences, Section of Pharmacology, and National Institute of Neuroscience, University of Ferrara, Ferrara, Italy; 4Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.
36- HIGH FAT DIET INDUCES CHANGES IN THE GUT MICROBIOTA, ANXIETY-LIKE BEHAVIOR, AND SEROTONERGIC SYSTEMS WITHIN THE DORSAL RAPHE NUCLEUS IN ADULT MALE WISTAR RATS
Noronha SISRa,b, Campos GSVa, Abreu ARc, Lima PMa, StamperCEb, Arnold MRb, HassellJEb,d, HeinzeJDb, LiebWMb, Chianca-Jr DAa, LowryCAb,d,e,f,g, Menezes RCAa*

All posteres should be hang there in the morning. Presentation times are as follows:

Morning (10:00-11:00): posters 1-18

1- MATERNAL SEPARATION STRESS INFLUENCES ALCOHOL CONSUMPTION IN THE ADULTHOOD. Natalia Bonetti Bertagna 1, Augusto Anesio1, Paola Palombo1, Thaís Sueme Yokoyama 1, Tarciso Tadeu Miguel2, Fábio Cardoso Cruz1 ¹ Pharmacology Department, Federal University of São Paulo (UNIFESP). ² Pharmacology Departament, Federal University of Uberlândia (UFU

2-EVALUATION OF POLYGALA PANICULATA HYDROALCOHOLIC EXTRACT EFFECT IN STROKE MODELS IN VITRO AND IN VIVO Tassiane Emanuelle Servare Andrade1, Jhenifer Karvat1, Tamara Andrea Alarcon Ferreira2, Matthew Demmings3, Tiago Tizziani1, Cristina Martins e Silva2, Sean P. Cregan3, Adair Roberto Soares dos Santos1 1Department of Physiological Sciences, Federal University of Santa Catarina, Brazil; 2Department of Physiological Sciences, Federal University of Espirito Santo, Brazil; 3Robarts Research Institute, University of Western Ontario, Canada.

3-EVALUATION OF CELL VIABILITY IN CULTURE OF ASTROCYTES SUBMITTED TO TREATMENT WITH MAGNETIC STIMULATION Jéssica Marques Obelar Ramos1, Caroline Crespo da Costa1,2, André Peres Koth3, Giovana Duzzo Gamaro1,4, Izabel Cristina Custódio de Souza1,2 1Laboratory of Cultive and Neuromodulation Cell (NeuroCell group) – Institute of Biology, Federal University of Pelotas, 2Department of Morphology – Institute of Biology, Federal University of Pelotas – Pelotas, Brazil, 4Anhanguera College – Pelotas, Brazil, 4Department of Biochemistry – Center of Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas – Pelotas, Brazil

4-TREATMENT WITH AN ETHYL-ACETATE FRACTION (EAF) OF TRICHILIA CATIGUA (CATUABA) ALLEVIATES THE MEMORY IMPAIRMENT CAUSED BY GLOBAL CEREBRAL ISCHEMIA IN RATS Daniela Velasquez¹, Jacqueline Godinho, Anacharis Babeto de Sá Nakanishi2, Jurandir Fernando Comar2, João Carlos Palazzo de Mello³, Rúbia Maria Monteiro Weffort de Oliveira¹, Humberto Milani¹. ¹ Department of Pharmacology and Therapeutics, State University of Maringá. Maringá / PR, Brazil. 2Department of Biochemistry, State University of Maringá. Maringá / PR, Brazil. 3 Department of Pharmacy, State University of Maringá. Maringá/ PR, Brazil.

5-INVOLVEMENT OF MONOAMINES IN DEPRESSIVE- AND ANXIETY-LIKE BEHAVIORS IN AN ANIMAL MODEL OF PARKINSON’S DISEASE Daniele Cristina Ramos1, Jeane Cristina Fonseca Vieira2, Maria Aparecida Barbato Frazão Vital1 1Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil, 2Department of Neuroscience and Behavioral Sciences, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
6- AGOMELATINE’S EFFECT ON CIRCADIAN LOCOMOTOR RHYTHM ALTERATION AND DEPRESSIVE-LIKE BEHAVIOR IN 6-OHDA LESIONED RATS Leonardo C. Souza1, Bruno J. Martynhak2, Taysa B. Bassani1, Joelle de M. Turnes1, Meira M. Machado1, Eric Moura1, Roberto Andreatini1, Maria A.B.F. Vital1 1Pharmacology Department, Federal University of Paraná, Paraná, Brazil, 2Physiology Department, Federal University of Paraná, Paraná, Brazil

7- SPATIAL AND DISCRIMINATION MEMORY IMPAIRMENTS EXHIBITED BY LOW-DENSITY LIPOPROTEIN RECEPTOR (LDLR) KNOCKOUT MICE ARE ASSOCIATED WITH MOLECULAR SYNAPTIC CHANGES Gislaine Olescowicz1, Eduardo Luiz Gasnhar Moreira2, Andreza Fabro De Bem4, Rodrigo Leal de Barros3, Leandra Celso Constantino3, Rui Daniel Prediger1 1Depto Farmacologia, 2Depto Ciências Fisiológicas, 3 Depto Bioquímica – Universidade Federal de Santa Catarina – UFSC, 4Instituto de Ciências Biológicas – Universidade de Brasília- UnB.
8- CAFFEINE PLUS EXERCISE IMPROVES COGNITIVE AND EMOTIONAL IMPAIRMENTS AND SYNAPTIC PLASTICITY IN AN ANIMAL MODEL OF ADHD Bruna Soares de Souza1,2, Angela Patricia França1, Geison de Souza Izidio3, Rui Daniel Prediger1,2 1Neuroscience Graduate Program, Federal University of Santa Catarina, Florianópolis-SC, 2 Department of Pharmacology, Federal University of Santa Catarina, Florianópolis-SC, 3Department of Cell Biology, Embriology and Genetics, Federal University of Santa Catarina, Florianópolis-SC.
9- THE DIFFERENTIAL CONTRIBUTION OF PROTEIN KINASE C AND PKMΖ LOCATED IN PL CORTEX IN FEAR MEMORY RECONSOLIDATION AND PERSISTENCE Thiago Rodrigues da Silva1; Ana Maria Raimundy1; Leandro Bertoglio.2; Roberto Andreatini1; Cristina Jark Stern1. 1Dept. of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil. 2Dept. of Pharmacology, CCB, Federal University of Santa Catarina, Florianópolis, SC, Brazil.

10- COULD THE “BIASED” 5-HT1A RECEPTOR AGONISTS F15599 AND F13714 CHANGE THE PATTERN SEPARATION PERFORMANCE AND HIPPOCAMPAL PLASTICITY IN AGED RATS? Ligia Mendes Soares1, Rafael Pazinatto Aguiar1, Humberto Milani1, Mark Varney3, Adrian Newman-Tancredi3, Jos Prickaerts2, Rúbia Weffort de Oliveira1 ¹ Department of Pharmacology and Therapeutic, State University of Maringá. Maringá / PR, Brazil. 2University of Maastricht, Department of Psychiatry and Neuropsychology, Maastricht/ Netherlands. 3Neurolixis Inc., San Diego, California, United State of America.

11- NEURONAL ENSEMBLES MOLECULAR ADAPTATIONS AND INCUBATION OF COCAINE CRAVING Augusto Anesio1; Thais Suemi Yokoyama1, Caroline Riberti Zaniboni1, Paola Palombo1 Natalia Bertagna1, Fábio Cardoso Cruz1 Department of Pharmacology, Federal University of São Paulo, UNIFESP, São Paulo, SP, Brazil

12-EFFECTS OF ENVIRONMENTAL ENRICHMENT ON DEPRESSIVE-LIKE BEHAVIOR AND HIPPOCAMPAL NEUROPLASTICITY IN A MODEL OF HUNTINGTON DISEASE Evelini Plácido1, Ana Claudia Wink1, Cristine de Paula Nascimento de Castro1, Ana Lúcia Severo Rodrigues2, Joana Gil-Mohapel3, Patricia de Souza Brocardo1 1Laboratório de Neuroplasticidade, Departamento de Ciências Morfológicas; 2Laboratório de Neurobiologia de Depressão, Departamento de Bioquímica, UFSC – Universidade Federal de Santa Catarina, Florianópolis, SC; 3Division of Medical Sciences, UBC Island Medical Program, University of Victoria, Victoria, BC, Canada.
13- OBJECT RECOGNITION AND CONTEXTUAL FEAR MEMORYIMPAIRMENTS EXHIBITED BY YOUNG ADULT LOW-DENSITY LIPOPROTEIN RECEPTOR (LDLR) KNOCKOUT MICE ARE NOT ASSOCIATED WITH HIPPOCAMPAL ATROPHY Cibele Martins Pinho1, Gislaine Olescowicz1, Andreza Fabro de Bem2, Rui Daniel Schröder Prediger1, 1Departamento de Farmacologia, Universidade Federal de Santa Catarina – UFSC, Florianópolis, Brazil. 2Instituto de Ciências Biológicas – Universidade de Brasília- UnB, Brasília, Brazil.
14-BILATERAL INJECTION OF 6-HYDROXYDOPAMINE INTO THE DORSOLATERAL STRIATUM OF SHR AND SLA16 RATS Guilherme P. Fadanni1, Santiago C. Peralta1, Tuane B. Sampaio2, Katiane Roversi2, Rui D. Prediger2, Geison S. Izídio1 1Behavior Genetics Laboratory, Department of Cell Biology, Embryology and Genetics, Federal University of Santa Catarina, Florianópolis, Brazil, 2Neurodegenerative Diseases Experimental Laboratory, Department of Pharmacology, Federal University of Santa Catarina, Florianópolis, Brazil.
15-EFFECTS OF INHIBITION OF THE ENDOCANNABINOID 2-AG HYDROLYSIS IN THE DORSOLATERAL PERIAQUEDUCTAL GRAY MATTER OF RATS IN THE CONTEXTUAL FEAR-CONDITIONING TEST Rayssa Brianis de Oliveira Costa1, Rita de Cassia Lima Xavier1, Fabricio Araujo Moreira1, Daniele Cristina de Aguiar1. 1Laboratory of Neuropsychopharmacology (LNP), Department of Pharmacology, Institute of Biological Sciences (ICB), Federal University of Minas Gerais (UFMG), Minas Gerais, Brazil.
16- CONDITIONED PLACE PREFERENCE TO COCAINE IN LEPTIN RECEPTOR DEFICIENT DIABETIC (DB/DB) MICE Júlia Ariana de Souza Gomes Lenzi1,2, Pedro Henrique Gobia2,3, Dayane Araújo Godinho3, Fabrício Araújo Moreira3, Daniele Cristina de Aguiar3 1 Institute of Biotechnology, Federal University of Uberlândia, Patos de Minas, MG, Brazil; 2 Neuropsicopharmacology Laboratory. Department of Pharmacology. Federal University of Minas Gerais, Belo Horizonte, MG, Brazil; 3 Department of Physics and Chemistry, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
17-EXERCISE DID NOT CHANGE THE CORTICOSTRIATAL METAPLASTICITY IN L-DOPA-INDUCED DYSKINESIA IN 6-HYDROXYDOPAMINE-LESIONED MICE 1,2, Ana Elisa Speck., 1,3, Aderbal Silva Aguiar Junior, 4,5, Rodrigo Antunes da Cunha., 1,2, Rui Daniel Schroder Prediger. 1Programa de Pós-Graduação em Neurociências, Universidade Federal de Santa Catarina, Santa Catarina/SC, Brazil, 2Departamento de Farmacologia, Universidade Federal de Santa Catarina, Santa Catarina/SC, Brazil, 3Departamento de Ciências da Saúde, Universidade Federal de Santa Catarina, Santa Catarina/SC, Brazil; 4,5Centro de Neurociências e Biologia Celular, Faculdade de Medicina, Universidade de Coimbra, Coimbra, Portugal.

18- PROTECTIVE EFFECT OF PROBUCOL AFTER MANGANESE-INDUCED MITOCHONDRIAL NEUROTOXICITY IN SH-SY5Y CELL LINE Erica Blanda daSilva1, Karina Giacomini Varela2, Dirleise Colle3, Marcelo Farina4, Diego Carvalho5, Aline Pertile Remor5 1Graduanda do curso de Medicina, ACVS, UNOESC, Brazil, 2Graduada em Ciências Biológicas, ACVS, UNOESC, Brazil, 3Departamento de Análises Clínicas, CCS, UFSC, Brazil, 4Departamento de Bioquímica, CCB, UFSC, Brazil, 5Programa de Pós-Graduação em Biociências e Saúde, ACVS, UNOESC, Brazil.

Afternoon  (15:30-16:30): posters 19-36

19- EFFECT OF PHOSPHODIESTERASE-4 INHIBITOR ROFLUMILAST ON THE EXTINCTION AND GENERALIZATION OF CONTEXTUAL CONDITIONED FEAR MEMORY IN STREPTOZOTOCIN-INDUCED DIABETIC RATS Ana Paula Farias Waltrick 1, Ana Carolina Felipe da Silva 1, Jos Prickaerts 2, Rúbia Maria Monteiro Weffort de Oliveira 3, Janaina Menezes Zanoveli 1,4 1 Department of Pharmacology, Federal University of Paraná, Curitiba, Parana, Brazil, 2 School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands, 3 Department of Pharmacology and Therapeutics, State University of Maringa, Maringa, Parana, Brazil, 4 Institute of Neurosciences and Behavior (INeC), University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil.
20- SOCIAL BEHAVIOR AND ENDOCANNABINOID-MEDIATED PLASTICITY IN THE NUCLEUS ACCUMBENS OF ADULT MICE EXPOSED TO WIN55,212-2 DURING JUVENILE PERIOD Patricia Felix Rolo Gonçalves1, Milene Borsoi2, Olivier Lassale2, Olivier Manzoni2, Newton Gonçalves de Castro1, Gilda Neves1 1 Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. 2 Institut de Neurobiologie de la Méditerranée, Institut National de la Santé et de la Recherche Médicale U1249, Marseille, France.
21- ACUTE INHIBITION OF PHOSPHODIESTERASE 4 WITH IMPROVES EXTINCTION PERSISTENCE Jeferson Machado Batista Sohn1, Suzen Tortato Furtado de Souza1, Ana Maria Raymundi1, Rúbia Maria Monteiro Weffort de Oliveira2, Jos Prickaerts3, Cristina Aparecida Jark Stern1 1Dept. of Pharmacology, Federal University of Parana, Curitiba, PR, Brazil, 2Dept. of Pharmacy, University of Maringa, Maringa, PR, Brazil, 3School of Metal Health and Neuroscience, University of Maastricht, The Netherlands.
22. PREGABALIN FACILITATES THE ACQUISITION OF CONTEXTUAL AVERSIVE MEMORY EXTINCTION AND INDUCES A LONG-LASTING ANXIOLYTIC-LIKE EFFECT IN DIABETIC ANIMALS A.H.B.L, Silva¹; J.M. Zanoveli¹, 2 1 Department of Pharmacology, Biological Science Sector, Federal University of Paraná, Curitiba, Paraná, Brazil 2 Institute of Neurosciences and Behavior (INeC), University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil.
23- EPIGENETIC AND DEPRESSION IN PARKINSON’S DISEASE: WHAT IS THE ROLE FOR BDNF? Marissa Giovanna Schamne 1,2,3; Angela Patricia França 2; Bruna Soares de Souza 2; Aurélie Meyer 4, Edmar Miyoshi 1, Laurence Lanfumey 4, Rui Daniel S. Prediger 2 1 Programa de Pós-Graduação em Ciências Biomédicas, Departamento de Ciências Farmacêuticas, Universidade Estadual de Ponta Grossa, Ponta Grossa, PR, Brazil. 2 Programa de Pós-Graduação em Farmacologia, Departamento de Farmacologia, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil. 3 Departamento de Ciências Biológicas e da Saúde, Unicesumar, Ponta Grossa, PR, Brazil. 4 INSERM UMR S894, Centre de Psychiatrie et Neurosciences, Paris 75014, France.
24- EFFECTS OF THE CANNABIDIOL ON AVERSIVE MEMORY EXPRESSION AND RECONSOLIDATION IN FEMALE RATS Jaqueline Maisa Franzen1 , Felipe Vanz1 , Francisco Silveira Guimarães2 , Leandro José Bertoglio1 1 Department of Pharmacology. Federal University of Santa Catarina, Biological Sciences Center, Florianópolis, Brazil 2 Department of Pharmacology. School of Medicine, University of São Paulo, Ribeirão Preto, Brazil.
25- EFFECTS OF A TRPV1 BLOCKER IN THE DORSOLATERAL HIPPOCAMPUS IN THE CONTEXTUAL FEAR CONDITIONING MODEL Lia P. Iglesias1, Sofia Kühl Fonseca1, Fabricio A. Moreira1 Neuropsychopharmacology Laboratory, Pharmacology Department, ICB, Federal University of Minas Gerais.
26- RESVERATROL PREVENTS EDEMA FORMATION THROUGH THE REGULATION OF SUR1 EXPRESSION IN BRAIN MICRO-VASCULAR ENDOTHELIAL CELLS Ivan Alquisiras-Burgos1, Penelope Aguilera1 1 Lab. Patología Vascular Cerebral, Instituto Nacional de Neurología y Neurocirugía “Manuel Velasco Suárez”, Ciudad de México, 14269, México.
27- EFFECTS OF INOSINE ON OXIDATIVE STRESS PARAMETERS AND ACETYLCHOLINESTERASE ACTIVITY IN THE HIPPOCAMPUS OF RATS SUBMITTED TO AN EXPERIMENTAL MODEL OF ALZHEIMER’S DISEASE Juliana Neto Mendes de Moura, Fernanda Teixeira, Mayara Soares, Roselia Maria Spanevello Postgraduate Program in Biochemistry and Bioprospecting: Center of Pharmaceutical, Chemical and Food Sciences, UFPel, Capão do Leão Campus, Pelotas, RS, Brazil.
28-SELECTIVE INHIBITION OF PHOSPHODIESTERASE 4 BY ROFLUMILAST PREVENTS MEMORY IMPAIRMENTS AND ACTIVATES ANTI-INFLAMMATORY MECHANISMS IN THE HIPPOCAMPUS OF RATS SUBJECTED TO TRANSIENT GLOBAL CEREBRAL ISCHEMIA. Jéssica Mendes Bonato1, Erika Meyer1, Humberto Milani1, Jos Prickaerts2 and Rúbia Maria Weffort de Oliveira1. 1State University of Maringá, Department of Pharmacology and Therapeutics, Maringá, Paraná, Brazil. 2Maastricht University, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht, The Netherlands. 1State University of Maringá, Department of Pharmacology and Therapeutics, Maringá, Paraná, Brazil. 2Maastricht University, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht, The Netherlands.
29. ACCUMBAL ENDOCANNABINOID SIGNALING MEDIATES COCAINE CRAVING FOLLOWING PROLONGED ABSTINENCE Pedro H. Gobira1,3, Swarup Mitra1, Jennifer A. Martin1, Craig T. Werner1, David M. Dietz1,2 1Dept. of Pharmacology and Toxicology; Program in Neuroscience, The State University of New York at Buffalo, Buffalo, NY, USA 2 Department of Psychology, The State University of New York at Buffalo, Buffalo, NY, USA 3 Department of Physics and Chemistry, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
30- N-METHYL-D-ASPARTATE INJECTED INTO THE DORSAL PERIAQUEDUCTAL GRAY INDUCES EMOTIONAL SENSITIZATION AND FACILITATES THE ACQUISITION OF CONTEXTUAL FEAR MEMORY Cristiane R. Mochny1, Antonio P. Carobrez1 1Departamento de Farmacologia, CCB, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.
31- THE TEMPORAL PARTICIPATION OF HIPPOCAMPAL CB1, CB2 AND PPARΓ RECEPTORS IN THE CANNABIDIOL CONSOLIDATION IMPAIRING EFFECT Ana Maria Raymundi1✉, Thiago R. da Silva1, Aleksander R. Zampronio1, Francisco da S. Guimarães2, Leandro J. Bertoglio3, Cristina A. J. Stern1 1Department of Pharmacology, Federal University of Parana, Curitiba, PR, Brazil; 2Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil; 3Department of Pharmacology, Federal University of Santa Catarina, Florianopolis, SC, Brazil. ✉
32-FFECTS OF PRAMIPEXOLE ON ULTRASONIC VOCALIZATION AND DEPRESSIVE-LIKE BEHAVIOR IN ANIMAL MODEL OF PARKINSON’S DISEASE. Deborah Galvão Coelho da Silva1, Leonardo de Castro1, Danielle Cristina Ramos1, Maryana Albino Clavero1, Anderson Gustavo Santos1, Camila Pasquini de Souza1, Juliano Koslos2, Débora Dalla Vecchia3, Silvio Marques Zanata2, Roberto Andreatini1, Maria Aparecida Barbato Frazão Vital1* 1Departament of Pharmacology, Federal University of Paraná, Curitiba, Paraná, Brazil. 2Departament of Pathology, Federal University of Paraná, Curitiba, Paraná, Brazil. 3 University Center Campos de Andrade, Curitiba, Paraná, Brazil.
33- MUSCIMOL INFUSIONS INTO THE INFRALIMBIC CORTEX DURING CONTEXTUAL FEAR MEMORY CONSOLIDATION INCREASE GENERALIZED DEFENSIVE RESPONSES AND HAMPER EXTINCTION Hugo Bayer Reichmann1 and Leandro José Bertoglio1 1Neuropsychopharmacology lab, Pharmacology Department, Biological Sciences Center, Federal University of Santa Catarina, Florianópolis – SC.
34- EVALUATION OF THE DOPAMINERGIC SYSTEM IN ZEBRAFISH SUBMITTED TO THE EXPOSURE MODEL TO ALCOHOLIC BINGE Samira Leila Baldin*¹, Maria Cecilia Manenti Alexandre 1,4 , Niuany Viel Mendes¹, Carolina Antunes Torres¹, Henrique Teza Bernardo¹, Rahisa Scussel², Emily da Silva Córneo², Suelen Baggio³, Maria Inês da Rosa 4 , Eduardo Pacheco Rico¹. 1 Laboratory of Experimental Neurology. Post-Graduation Program in Health Sciences, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil. 2 Laboratory of Experimental Physiology, Post-Graduation Program in Health Sciences, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil. 3 Department of Biochemistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil. 4 Laboratory of Translational Biomedicine, Post-Graduation Program in Health Sciences, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil.
35- NEUROCHEMICAL AND BEHAVIORAL CHANGES AFTER WEEKLY-BINGE EXPOSURE TO ETHANOL IN ZEBRAFISH Henrique Teza Bernardo1, Jotele Fontana Agostini1, Helena Cristina Zuehl Dal Toé1, Karine Medeiros Vieira1, Samira Leila BaldiN1, Carolina Uribe-Cruz3, Larisse Longo3, Themis Reverbel da Silveira3, Denis Broock Rosemberg4,5, Patrícia Fernanda Schuck2, Eduardo Pacheco Rico1 1 Laboratory of Neuronal Signaling and Psychopharmacology, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina (UNESC), Criciúma, Santa Catarina, Brazil. 2 Laboratório de Erros Inatos do Metabolismo, Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil. 3 Experimental Laboratory of Hepatology and Gastroenterology, Center for Experimental Research, Hospital de Clínicas de Porto Alegre, Graduate Program in Gastroenterology and Hepatology Sciences, Federal University of Rio Grande do Sul , Porto Alegre, Brazil. 4 Laaboratory of Experimental Neuropsychobiology, Department of Biochemistry and Molecular Biology, Natural and Exact Sciences Center, Federal University of Santa Maria, 1000 Roraima Avenue, Santa Maria, RS, 97105-900, Brazil. 5 The International Zebrafish Neuroscience Research Consortium (ZNRC), 309 Palmer Court, Slidell, LA 70458, USA.
36-THALAMIC NUCLEUS REUNIENS AND MEMORY UPDATING Fernanda Troyner 1, Leandro José Bertoglio 1 1 Universidade Federal de Santa Catarina. Department of Pharmacology. Florianópolis, SC, Brazil.