II Simpósio Brasileiro de Neuropsicofarmacologia

All posteres should be hang there in the morning. Presentation times are as follows:

Morning (10:00-11:00): posters 1-19

1 -ROLE OF NITRIC OXIDE IN THE ACQUISITION OF OLFACTORY AVERSIVE CONDITIONING INDUCED BY N-METHYL-D-ASPARTATE INFUSION INTO THE PERIAQUEDUCTAL GRAY MATTER Lucía Acuña1, Antonio P. Carobrez1 1Laboratory of Behavioral Neurobiology. Department of Pharmacology / CCB, UFSC, Florianópolis, SC, Brazil
2- ANTIDEPRESSANT-LIKE EFFECT OF GUANOSINE INVOLVES ACTIVATION OF AMPA RECEPTORS AND BDNF/TRKB PATHWAY Priscila B. Rosa1, Luis E. B. Bettio2, Vivian B. Neis1, Morgana Moretti1, Isabella A. Heinrich1, Andiara E. Freitas1, Mauren K. Tavares1, Rodrigo B. Leal1, Ana Lúcia S. Rodrigues1 1Department of Biochemistry, Center of Biological Sciences, Universidade Federal de Santa Catarina, Florianópolis, 88040-900, SC, Brazil. 2 Current address: Division of Medical Sciences, University of Victoria, Victoria, BC, Canada

3- ULIGINOSIN B INHIBITS ATP AND ADP HYDROLYSIS ON STRIATAL SYNAPTOSOMES OF RATS Camila Pires Machado da Silva1, Roberta Andrejew2, Caroline Guerra Marangon1, Gilsane Lino Von Poser1, Ana Maria Oliveira Batasttini2, Stela Maris Kuze Rates1 1Graduate Program in Pharmaceutical Sciences, Federal University of Rio Grande of Sul-UFRGS, Porto Alegre, RS, Brazil. 2 Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande of Sul-UFRGS, Porto Alegre, RS, Brazil.

4- PARTICIPATION OF THE P2X7-NLRP3 INFLAMMASOME PATHWAY IN STRESS SUSCEPTIBILITY AND ANTIDEPRESSANT RESPONSE IN THE LEARNED HELPLESSNESS MODEL : Roncalho AL1; Côrrea-Velloso JC2,3; Lacchini R4; Chiavegatto S5,6; Wegener G7; Joca SRL8 1Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil. 2 Department of Biochemistry, Chemistry Institute, University of Sao Paulo, Sao Paulo, Brazil, São Paulo, Brazil. 3 Department of Pharmacology, Physiology and Neuroscience, New Jersey Medical School, Rutgers, The State University of New Jersey, USA. 4Department of Psychiatric Nursing, Ribeirão Preto College of Nursing, University of Sao Paulo, Ribeirão Preto, Brazil. 5Department of Pharmacology, Biomedical Sciences Institute, University of São Paulo, São Paulo, Brazil 6Department and Institute of Psychiatry, Clinics Hospital, School of Medicine, University of São Paulo, Brazil 7Institute for Basic Psychiatric Research, Department of Biological Psychiatry, Aarhus University, Denmark. 8Department of Physics and Chemistry, School of Pharmaceutical Sciences of Ribeirão Preto, Brazil

5- DO GENETIC VARIATIONS OF THE NLRP3 GENE INTERFERE IN INTERLEUKIN-1Β LEVELS AND MAJOR DEPRESSIVE DISORDER DIAGNOSIS? Bruna C. Pierone1, Fernanda N. Kaufmann1, Clarissa R. Bastos2, Karen Jansen2, Luciano D. M. Souza2, Diogo R. Lara3, Ricardo A. Silva2, Gabriele Ghisleni2, Manuella P. Kaster1 1Department of Biochemistry, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil 2Department of Life and Health Sciences, Catholic University of Pelotas, Pelotas, Rio Grande do Sul, Brazil 3Department of Cellular and Molecular Biology, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil

6-  FLUOXETINE ENHANCES THE ANXIETY-LIKE BEHAVIOR INDUCED BY THE ELEVATED T-MAZE IN MICE Darlei Francisco Stein¹, Ana Luiza de Azevedo Gomes¹ e Stela Maris Kuze Rates¹ Programa de Pós-Graduação em Ciências Farmacêuticas, UFRGS, Brazil

7- THE USE OF RELIABILITY MEASUREMENTS IN THE FORCED SWIM TEST (FST) IN RATS: PROBING THE EFFECTS OF EXPERIENCE ON RATER´S PERFORMANCE. Giancarlo Marchesini1, João A. Marcolan1, Karolina Domingues2, Patrick Suman2, Cilene Lino de Oliveira2, José Marino Neto1 1Institute of Biomedical Engineering, Federal University of Santa Catarina, Florianópolis, SC, Brazil. 2Department Physiological Sciences, Federal University of Santa Catarina, Florianópolis, SC, Brazil.

8- PROLONGED TREATMENT WITH A PHOSPHODIESTERASE 4 INHIBITOR DID NOT INDUCE ANXIETY-LIKE BEHAVIOR OR NEGATIVE AFFECTIVE STATE IN RATS Maryana Albino Clavero1, Camila Pasquini de Souza1, Jos Prickaerts2, Rubia M. W. de Oliveira3, Roberto Andreatini1 1 Department of Pharmacology, Biological Sciences Sector, Federal University of Paraná, Centro Politécnico, C.P. 19031, 81540-990, Curitiba, Paraná, Brazil. 2. Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands. 3. Department of Pharmacology and Therapeutics, State University of Maringá, Av. Colombo, 5790, 87020-900, Maringá, Paraná, Brazil.

9- CB1 RECEPTOR ANTAGONISM PREVENTS HYPERLOCOMOTION INDUCED BY THE DOPAMINE TRANSPORTER INHIBITOR GBR12909 Juliana dos Reis Bastos 1, Nicole Font 1, Antônio Lúcio Teixeira Júnior 4,5, Fabiana Simão Machado 2, Aline Silva de Miranda 3,4, Fabrício de Araújo Moreira 1 1Department of Pharmacology, 2 Department of Biochemistry and Immunology, 3 Department of Morphology, 4 Interdisciplinary Laboratory of Medical Investigation, School of Medicine, Federal University of Minas Gerais – UFMG, BH, MG, Brazil; 5 Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA

10- EVALUATUION OF MICE LIMBIC BRAIN AREAS IN THE MODULATION OF RAT EXPOSURE TEST-EVOKED RESPONSE FERNANDES GJD2, BALBO LC1, BERTAGNA NB2, QUEIROZ RM2, GARCIA BS1, CRUZ FC3, MIGUEL TT1,2 ¹Pharmacology Department, Federal University of Uberlandia (UFU).²Cellular and Structural Applied Biology Graduate Program, UFU.³Psychopharmacology Department, Federal University of Sao Paulo (UNIFESP)

11- BEHAVIORAL AND NEUROCHEMICAL CHANGES IN MICE ADULTHOOD INDUCED BY EARLY LIFE STRESS Platt, N.1; Oliveira, E1.; Camargo, A.1; Kaufmann, F.N.1; Pieroni, B.1; Rosa, P.B.1; Rosado, A.F.1; Olescowicz, G.2; Rodrigues, A.L.S.1; Prediger, R. D. S.2; Brocardo, P.S.3; Kaster, M.P1. 1Department of Biochemistry, Federal University of Santa Catarina – Campus Reitor João David Ferreira Lima – Trindade/Florianópolis – SC, 88040-900 2Department of Pharmacology, Federal University of Santa Catarina – Campus Reitor João David Ferreira Lima – Trindade/Florianópolis – SC, 88040-900 3Department of Neuroscience, Federal University of Santa Catarina – Campus Reitor João David Ferreira Lima – Trindade/Florianópolis – SC, 88040-900

12- IMPACT OF STRESS DURING PREGNANCY ON CHILD DEVELOPMENT: ROLE OF HYPOTHALAMIC-PITUITARY-ADRENAL AXIS ACTIVATION Angelina da Silva Pires, Cristiane Rezende Mochny CESUSC College, Florianópolis, SC, Brazil.

13- COMPARISON OF ADVERSE EVENTS OF VALPROATE SODIUM 300 MG TABLET COATED UNDER FASTED CONDITIONS AND FED AFTER ORAL ADMINISTRATION Patrícia Moura da Rosa Zimmermann1, Emanuelle Menegazzo Webler1, Júlia Pacheco2, Carmen Maria Donaduzzi1, Letícia Mello Rechia1, Antonio Waldo Zuardi2, Liberato Brum Junior1 1 Prati Donaduzzi & Cia LTDA 2 Department of Neuroscience and Behavior, FMRP, University of São Paulo, Ribeirão Preto, SP, Brazil.

14- FOOD DEPRIVATION AND SEARCH FOR PALATABLE FOOD IN FRUIT FLIES: INTERACTIONS BETWEEN SEX AND DURATION OF FASTING Fabiola Boz Eckert1, Daniela Cristina De Toni2, Cilene Lino De Oliveira3, José Marino Neto4. 1Postgraduate Program in Pharmacology, Federal University of Santa Catarina -UFSC, Brazil,2Drosofilids Laboratory, UFSC, Brazil,3Laboratory of Behavioural Neurobiology, UFSC, Brazil, 4Institute of Biomedical Engineering, UFSC, Brazil

15- CHRONIC GLIBENCLAMIDE TREATMENT PREVENTED STRESS-INDUCED CHANGES IN BEHAVIOR AND DOPAMINE LEVELS IN THE PRE-FRONTAL CORTEX OF MICE Axel Fogaça Rosado¹, Fernanda Neutzling Kaufmann¹, Priscila Batista Rosa¹, Vivian Binder Neis¹, Gudrian Ricardo Lopes de Almeida¹, Ingrid Selhorst¹, Alcir Luiz Dafre¹, Ana Lúcia Severo Rodrigues¹, Manuella Pinto Kaster¹ Department of Biochemistry, Federal University of Santa Catarina

16- THE ACUTE EFFECTS OF LOW DOSES OF ∆9-TETRAHIDROCANABINOL IN ANXIETY ARE SEX AND AGE-DEPENDENT Beatriz Zanutto Salviato1, Thiago Rodrigues da Silva1, Ana Maria Raymundi1, Cristina Aparecida Jark Stern1 1Department of Pharmacology, Biological Sciences Center. Federal University of Parana, Curitiba, PR, Brazil.

17- FASTING INCREASE THE PREFERENCE FOR PALATABLE FOOD IN DROSOPHILA MELANOGASTER Fabiani Fernanda Triches1,3; Fabiola Boz Eckert1,3; Mauro Federico Ramírez2; Ana Belen Ramos Hryb3; Daniela Cristina de Toni1; Cilene Lino de Oliveira3 1Drosofilids Laboratory, CCB, Federal University of Santa Catarina, Brazil 2Laboratory of Comparative Neurophysiology, Department of Physiological Sciences, CCB, Federal University of Santa Catarina, Brazil 3Laboratory of Behavioral Neurobiology, CCB, Federal University of Santa Catarina, Brazil

18- ROLE OF µ-OPIOID AND CB1 RECEPTORS OF THE DORSAL PERIAQUEDUCTAL GRAY MATTER IN THE MODULATION OF AVERSIVE AND ANTINOCICEPTIVE RESPONSES INDUCED BY FEAR Godoi, Manuella Machado 1; Cunha, Joice Maria 1,2; Zanoveli, Janaina Menezes, 1,2 1 Department of Pharmacology, Biological Science Sector, Federal University of Paraná, Curitiba, Paraná, Brazil 2 Institute of Neurosciences and Behavior (INeC), University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil

19- MYNOCICLINE PRE-TREATMENT DID NOT PREVENT THE BEHAVIORAL CHANGES INDUCED BY HIGH-REFINED CARBOHYDRATE DIET CONSUMPTION IN MICE Nícia Pedreira Soares1; Anna Paula Marçal1; Rafaela Pinto Coelho Santos1 Laila Asth1, Daniele Cristina de Aguiar1 1Laboratory of Neuropsychopharmacology (LNP), Department of Pharmacology, Institute of Biological Sciences (ICB), Federal University of Minas Gerais (UFMG), Minas Gerais, Brazil

Afternoon  (15:30-16:30): posters 20-36

20- A SINGLE INJECTION OF THE ORGANOPHOSPHORUS TRIAZOPHOS INDUCES A DEPRESSIVE, BUT NOT AN ANXIOUS-LIKE BEHAVIOR IN RATS Anna Paula Perin Vidigal, Julia Gomes dos Santos, João Vitor Ferreira Rodrigues, Vitor Sampaio Minassa, Thatiany Jardim Batista, Karla Nívea Sampaio, Vanessa Beijamini Harres Pharmaceutical Sciences Graduate Program, Health Sciences Center, Federal University of Espirito Santo, Vitoria, Brazil

21- VERTICAL CLIMBING: MEASURING THE MOTIVATION OF RATS IN AN EFFORT TASK Tamires Martins1; Renato Fiacador de Lima1; Cilene Lino de Oliveira1. 1 Department of Physiological Sciences, Center of Biological Science, Federal University of Santa Catarina, Florianópolis, Brazil.

22- THE USE OF RELIABILITY METRICS FOR OBSERVATIONAL STUDIES IN RATS SUBMITTED TO THE FORCED SWIM TEST (FST): A SYSTEMATIC REVIEW. Giancarlo Marchesini1, Cilene Lino de Oliveira2, José Marino Neto1 1Institute of Biomedical Engineering, Federal University of Santa Catarina, Florianópolis, SC, Brazil, 2Department Physiological Sciences, Federal University of Santa Catarina, Florianópolis, SC, Brazil

23- CANNABIDIOL AS A POTENTIAL THERAPEUTIC AGENT IN THE TREATMENT OF DEPRESSION AND ANXIETY ASSOCIATED WITH DIABETES Yane Chaves1, Karina Genaro2,3, Cristina Stern1, José Alexandre Crippa4,5, Joice Maria Cunha1,2, Janaína Menezes Zanoveli1,2 1Department of Pharmacology, Biological Science Sector, Federal University of Paraná, Curitiba, Paraná, Brazil, 2Institute of Neurosciences and Behavior (INeC), University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil, 3University of California, Irvine, Department of Pharmacology, Irvine, California, United States of America, 4Department of Neuroscience and Behavioral Sciences, Ribeirão Preto Medical School, University of São Paulo, Brazil, 5National Institute of Science and Technology for Translational Medicine (INCT-TM-CNPq), Ribeirão Preto, São Paulo, Brazil

24- ACUTE TREATMENT WITH CANNABIDIOL DID NOT PREVENT THE COMPULSIVE-LIKE BEHAVIOR IN MICE AFTER CONSUMPTION OF HIGH-REFINED CARBOHYDRATE DIET Anna Paula Marçal1; Nícia Pedreira Soares1; Dayane Araújo1; Daniele Cristina de Aguiar1 Laboratory of Neuropsychopharmacology (LNP), Department of Pharmacology, Institute of Biological Sciences (ICB), Federal University of Minas Gerais (UFMG), Minas Gerais, Brazil

25- SEX DIFFERENCES IN THE BEHAVIORAL RESPONSE OF SEROTONERGIC INHIBITION OF THE MEDIAL PRE-FRONTAL CORTEX IN RATS SUBMITTED TO THE FORCED SWIMMING TEST Karolina Domingues1, Fernando Falkenburger Melleu2, Patrick Remus Suman1, Tamires Martins1, Cilene Lino de Oliveira1 1Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil; 2Universidade de São Paulo, São Paulo, SP, Brazil

26- A PROTOCOL FOR THE SYSTEMATIC REVIEW AND META-ANALYSIS OF THE EVIDENCE LINKING HIPPOCAMPAL NEUROGENESIS TO THE EFFECTS OF ANTIDEPRESSANTS ON MOOD AND BEHAVIOR Juliana Aparecida Bolzan1, Cilene Lino de Oliveira2 ¹ Master student in Pharmacology. Laboratory of Behavioral Neurobiology, Labnec-CFS-CCB-UFSC- Florianopolis-SC-Brazil. E-mail: ² Advisor of the Graduate Program in Pharmacology. Laboratory of Behavioral Neurobiology, Labnec-CFS-CCB-UFSC- Florianopolis-SC-Brazil.
27- BEHAVIOURAL EVALUATION AND SEXUAL DIFFERENCES AFTER MATERNAL SEPARATION IN WISTAR RATS Patrick Remus Suman¹,², Tamires Martins², Karolina Domingues¹,², Cilene Lino de Oliveira¹,³ 1.Department of Pharmacology, Center of Biological Sciences, Federal University of Santa Catarina – UFSC, Florianópolis, SC, Brazil 2. Department of Physiological Sciences, Center of Biological Sciences, Federal University of Santa Catarina – UFSC, Florianópolis, SC, Brazil
28- THE MONOAMINE STABILIZER, OSU-6162, REDUCES COCAINE-INDUCED HYPERLOCOMOTION AND ACQUISITION OF CONDITIONED PLACE PREFERENCE IN MICE Laila Asth1, Nícia Pereira Soares1, Anna Paula Marçal1, Daniele Cristina Aguiar1, Fabrício de Araújo Moreira1 1Laboratory of Neuropsychopharmacology, Department of Pharmacology, ICB, Federal University of Minas Gerais, Brazil
29- THE USE OF ANTIDEPRESSANTS IN THE PRIMARY CARE: PROFILE OF USERS IN A MUNICIPALITY IN THE WEST OF SANTA CATARINA Patrícia Prevedello 1, Cilene Lino de Oliveira 2 1 Municipality of Maravilha, Primary care pharmacist, Maravilha, SC, Brazil, 2 Department of pharmacology, CCB, UFSC, Florianópolis, SC, Brazil

30- THE ANTIDEPRESSANT EFFECT OF KETAMINE IN SWISS MICE IN THE FORCED SWIM TEST: SYSTEMATIC REVIEW AND META-ANALYSIS OF LITERATURE EVIDENCE Silva, Marcus Antônio Bezerra1; Zerbinatti, Nathália1; Suman, Patrick Remus1; Lino de Oliveira, Cilene1 Department of Physiological Sciences, Federal University of Santa Catarina, Florianopolis, SC, Brazil.

31-AEROBIC EXERCISE ATTENUATES HYPERALGESIA SIGNS INDUCED BY FIBROMYALGIA MODEL Eduarda Gomes Ferrarini1,2, Elaine Cristina Dalazen Gonçalves1,2, Jaíne Ferreira Menegasso1, Rafael Cypriano Dutra1,2 1 Laboratório de Autoimunidade e Imunofarmacologia, Departamento de Ciências da Saúde, Universidade Federal de Santa Catarina, Campus Araranguá, Araranguá, SC, Brasil. 2 Programa de Pós-Graduação em Neurociências, Centro de Ciências Biológicas, Campus Florianópolis, Universidade Federal de Santa Catarina, Florianópolis, SC, Brasil.
32- OXYTOCIN RECEPTOR MODULATES ANXIOGENIC LIKE BEHAVIOR IN PSYCHOLOGICAL STRESS Ivaldo Jesus Almeida Belem-Filho1, Alana Tercino Frias1, Hélio Zangrossi-Junior1, Jose Antunes-Rodrigues2, Fernando Morgan de Aguiar Corrêa1 1Department of Pharmacology, Faculty of Medicine of Ribeirão Preto, Ribeirão Preto, São Paulo, Brazil, 2Department of Physiology, Faculty of Medicine of Ribeirão Preto, Ribeirão Preto, São Paulo, Brazil.
33- POTENTIAL ANTIMANIAC EFFECT OF QUERCETIN ON HYPERLOCOMOTION INDUCED BY OUABAIN IN ANIMAL MODELS OF MANIA Vivian C. Monteiro Pereira1, Roberto Andreatini1, Ana Paula Segantine1 1Department of Pharmacology, Federal University of Paraná/UFPR, Curitiba, PR, Brazil.
34- THE ANTIDEPRESSANT EFFECT OF RAPANEA FERRUGINEA AND ITS MAJORITARY COMPOUND MYRSINOIC ACID B IN DIABETIC RATS IS ASSOCIATED WITH A REDUCTION OF THE OXIDATIVE STRESS IN THE PREFRONTAL AND HIPPOCAMPAL CORTICES Priscila Laiz Zimath¹; Ana Paula Dalmagro²; Luisa Mota Silva²; Angela Malheiros²; Márcia Maria de Souza². ¹ Programa de Pós Graduação em Farmacologia, Universidade Federal de Santa Catarina, SC, Brasil. ² Programa de Pós Graduação em Ciências Farmacêuticas, Universidade do Vale do Itajaí, SC, Brasil.
35- MODULATION OF THE NOP RECEPTOR SIGNALING AFFECTS STRESS COPING RESPONSES IN MICE: IMPLICATIONS FOR RESILIENCE TO STRESS Holanda VAD1, Pacifico S2, Azevedo Neto J3, Finetti L4, Calo’ G3, Ruzza C3, Gavioli EC1 1Behavioral Pharmacology Laboratory, Department of Biophysics and Pharmacology, Federal University of Rio Grande do Norte, Natal, Brazil; 2Department of Chemistry and Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy; 3Department of Medical Sciences, Section of Pharmacology, and National Institute of Neuroscience, University of Ferrara, Ferrara, Italy; 4Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.
36- HIGH FAT DIET INDUCES CHANGES IN THE GUT MICROBIOTA, ANXIETY-LIKE BEHAVIOR, AND SEROTONERGIC SYSTEMS WITHIN THE DORSAL RAPHE NUCLEUS IN ADULT MALE WISTAR RATS
Noronha SISRa,b, Campos GSVa, Abreu ARc, Lima PMa, StamperCEb, Arnold MRb, HassellJEb,d, HeinzeJDb, LiebWMb, Chianca-Jr DAa, LowryCAb,d,e,f,g, Menezes RCAa*